The Developmental Origin of Calcific Aortic Stenosis
Aikawa E, Hutcheson JD. N Engl J Med. 2022 Apr 7;386(14):1372-4. PMID: 35388675. View Article
Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition
Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian…
Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling
Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP,…
Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8 + T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease
Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO,…
Calcific Aortic Valve Disease: From Molecular and Cellular Mechanisms to Medical Therapy
Kraler S, Blaser MC, Aikawa E, Camici GG, Lüscher TF. Eur Heart J. 2022 Feb 12;43(7):683-97. PMID: 34849696. PMC8843796. View…
Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis
Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E.…
Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty
Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia…
Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost
Human P, Bezuidenhout D, Aikawa E, Zilla P. Front Cardiovasc Med. 2022 Jan 4;8:760635. PMID: 35059444. PMC8764456. View Article
Controlled Delivery of Gold Nanoparticle-Coupled miRNA Therapeutics via an Injectable Self-Healing Hydrogel
van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer…
Innate and Adaptative Immunity: The Understudied Driving Force of Heart Valve Disease
Bartoli-Leonard F, Zimmer J, Aikawa E. Cardiovasc Res. 2021 Nov 22;117(13):2506-24. PMID: 34432007. PMC8783388. View Article
Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC. Front…
Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients
Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA,…