Unbiased Omics Identifies Mechanistic Regulators of Calcific Aortic Valve Disease
Rogers MA, Aikawa E. Eur Heart J. 2021 Aug 7;42(30):2948-50. PMID: 34179985. PMC8095786. View Article
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA,…
ApoA-I Mimetics Improve Aortic Stenosis-Associated Left-Ventricular Diastolic Dysfunction but Fail to Benefit Rabbit Models With Normal Aortic Valves
Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF. Int J Cardiol. 2021 Jun 1;332:159-61. PMID: 33626387.…
Old Drugs for an Old Pathology?
Bartoli-Leonard F, Aikawa E. Circ Res. 2021 Apr 30;128(9):1317-9. PMID:33914606. PMC8095786. View Article
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis
Blaser MC, Kraler S, Lüscher TF, Aikawa E. Circ Res. 2021 Apr 30;128(9):1371-97. PMID: 33914608. PMC8095729. View Article
Nitric Oxide Prevents Aortic Valve Calcification by S-nitrosylation of USP9X to Activate NOTCH Signaling
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa…
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO,…
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms
Passos LSA, Nunes MCP, Aikawa E. Front Cardiovasc Med. 2021 Jan 18;7:612716. PMID: 33537348. PMC7848031. View Article
ApoC-III Is a Novel Inducer of Calcification in Human Aortic Valves
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia…
2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders
Aikawa E, Blaser MC. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):117-27. PMID: 33115271. PMC7832175. View Article
Calcific Aortic Valve Disease “Omics” Is Timely, But Are We Looking Too Late?
Atkins SK, Singh SA, Aikawa E. JACC Basic Transl Sci. 2020 Dec 28;5(12):1178-80. PMID: 33427821. PMC7775952. View Article
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes
Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP,…