Rheumatic Heart Valve Disease: Navigating the Challenges of an Overlooked Autoimmune Disorder
Lupieri A, Jha PK, Nizet V, Dutra WO, Nunes MCP, Levine RA, Aikawa E. Front Cardiovasc Med. 2025 Mar 13;12:1537104.…
Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification: Implications for DNA Methyltransferase-1 Activity
Song N, Ji E, Yu JE, Choi KH, Kim DH, Song JM, Kang DH, Song JK, Yu J, Kim K,…
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes
Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle…
Calcific Aortic Stenosis: Omics-based Target Discovery and Therapy Development
Blaser MC, Bäck M, Lüscher TF, Aikawa E. Eur Heart J. 2025 Feb 14;46(7):620-634. PMID: 39656785. PMC11825147. View Article
Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA Sequencing
Villa-Roel N, Park C, Andueza A, Baek KI, Su A, Blaser MC, Leshnower BG, Yoganathan A, Aikawa E, Jo H.…
Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association
Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C;…
Intervention for Critical Aortic Stenosis in Hutchinson-Gilford Progeria Syndrome
Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy…
Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community
Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. PMID: 38536897. PMC10977651. View…
Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):822-825. PMID: 38357818.…
Multimodal Analytical Tools to Enhance Mechanistic Understanding of Aortic Valve Calcification
Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E. Am J Pathol. 2024 Apr;194(4):539-550. PMID: 37517686. PMC10988764. View Article
Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D-bioprinted Aortic Valve Arrays
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A,…
Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis
Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC,…