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Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction

Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA,…

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Can We Diagnose Acute Rheumatic Fever Early to Maximize the Success of Secondary Prophylaxis in Rheumatic Heart Valve Disease?

Passos LSA, Nizet V, Levine RA, Aikawa E. Cardiovasc Res. 2022 Jul 20;118(9):e62-e65. PMID: 35862716. View Article

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Progression of Aortic Stenosis After an Acute Myocardial Infarction

Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P,…

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A Disease-Driver Population Within Interstitial Cells of Human Calcific Aortic Valves Identified via Single-Cell and Proteomic Profiling

Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S,…

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The Developmental Origin of Calcific Aortic Stenosis

Aikawa E, Hutcheson JD. N Engl J Med. 2022 Apr 7;386(14):1372-4.PMID: 35388675. View Article

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Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition

Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian…

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Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling

Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP,…

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Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8 + T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease

Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO,…

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Calcific Aortic Valve Disease: From Molecular and Cellular Mechanisms to Medical Therapy

Kraler S, Blaser MC, Aikawa E, Camici GG, Lüscher TF. Eur Heart J. 2022 Feb 12;43(7):683-97. PMID: 34849696. PMC8843796. View…

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Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis

Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E.…

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Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty

Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia…

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Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost

Human P, Bezuidenhout D, Aikawa E, Zilla P. Front Cardiovasc Med. 2022 Jan 4;8:760635. PMID: 35059444. PMC8764456. View Article

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