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Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community

Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. PMID: 38536897; PMC10977651. View…

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Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D-bioprinted Aortic Valve Arrays

Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A,…

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Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum

Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E. Arterioscler Thromb Vasc Biol. 2024 Feb 15. PMID:…

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Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis

Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC,…

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Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease

Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA,…

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Valvulogenesis of a Living, Innervated Pulmonary Root Induced by an Acellular Scaffold

Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH,…

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CardioVision: A Fully Automated Deep Learning Package for Medical Image Segmentation and Reconstruction Generating Digital Twins for Patients With Aortic Stenosis

Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI,…

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Tissue Formation and Host Remodeling of an Elastomeric Biodegradable Scaffold in an Ovine Pulmonary Leaflet Replacement Model

Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer…

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PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R,…

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Multimodal Analytical Tools to Enhance Mechanistic Understanding of Aortic Valve Calcification

Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E. Am J Pathol. 2023 Jul 28:S0002-9440(23)00270-5. PMID: 37517686. View Article

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Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis

Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK,…

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Single-Cell T Cell Receptor Sequencing of Paired Tissue and Blood Samples Reveals Clonal Expansion of CD8+ Effector T Cells in Patients With Calcific Aortic Valve Disease

Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E.…

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