Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association
Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C;…
Intervention for Critical Aortic Stenosis in Hutchinson-Gilford Progeria Syndrome
Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy…
Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community
Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. PMID: 38536897. PMC10977651. View…
Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):822-825. PMID: 38357818.…
Multimodal Analytical Tools to Enhance Mechanistic Understanding of Aortic Valve Calcification
Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E. Am J Pathol. 2024 Apr;194(4):539-550. PMID: 37517686. PMC10988764. View Article
Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D-bioprinted Aortic Valve Arrays
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A,…
Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis
Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC,…
Tissue Formation and Host Remodeling of an Elastomeric Biodegradable Scaffold in an Ovine Pulmonary Leaflet Replacement Model
Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer…
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease
Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA,…
Valvulogenesis of a Living, Innervated Pulmonary Root Induced by an Acellular Scaffold
Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH,…
CardioVision: A Fully Automated Deep Learning Package for Medical Image Segmentation and Reconstruction Generating Digital Twins for Patients With Aortic Stenosis
Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI,…
PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves
Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R,…