Calcific Aortic Stenosis: Omics-based Target Discovery and Therapy Development
Blaser MC, Bäck M, Lüscher TF, Aikawa E. Eur Heart J. 2024 Dec 4:ehae829. PMID: 39656785. View Article
Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association
Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C; American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing. Circulation. 2024 Aug 6;150(6):e109-e128. PMID: 38881493. PMC11542557. View Article
Intervention for Critical Aortic Stenosis in Hutchinson-Gilford Progeria Syndrome
Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy A, Hegde SM, Kleinman ME, Maschietto N, Mehra MR, Mukundan S, Musumeci F, Russo M, Rybicki FJ, Shah PB, Suarez WA, Tuminelli K, Zaleski K, Prakash A, Gerhard-Herman M. Front Cardiovasc Med. 2024 Apr 25;11:1356010. PMID: 38725831. PMC11079313. View Article
Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community
Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. PMID: 38536897. PMC10977651. View Article
Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):822-825. PMID: 38357818. PMC10978236. View Article
Multimodal Analytical Tools to Enhance Mechanistic Understanding of Aortic Valve Calcification
Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E. Am J Pathol. 2024 Apr;194(4):539-550. PMID: 37517686. PMC10988764. View Article
Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D-bioprinted Aortic Valve Arrays
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E. Sci Adv. 2024 Mar;10(9):eadj9793. PMID: 38416823. PMC10901368. View Article
Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis
Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC, Thanassoulis G, Floyd J, Austin TR, Bortnick A, Kizer J, Freitas RCC, Singh SA, Aikawa E, Hoogeveen RC, Ballantyne C, Yu B, Coresh J, Blaha MJ, Matsushita K, Shah AM. J Am Coll Cardiol. 2024 Feb 6;83(5):577-591. PMID: 38296402. View Article
Tissue Formation and Host Remodeling of an Elastomeric Biodegradable Scaffold in an Ovine Pulmonary Leaflet Replacement Model
Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE Jr. J Biomed Mater Res A. 2024 Feb;112(2):276-87. PMID: 37772456. PMC11034854. View Article
CardioVision: A Fully Automated Deep Learning Package for Medical Image Segmentation and Reconstruction Generating Digital Twins for Patients With Aortic Stenosis
Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR. Comput Med Imaging Graph. 2023 Oct:109:102289. PMID: 37633032. PMC10599298. View Article