Innate and Adaptative Immunity: The Understudied Driving Force of Heart Valve Disease
Bartoli-Leonard F, Zimmer J, Aikawa E. Cardiovasc Res. 2021 Nov 22;117(13):2506-24. PMID: 34432007. PMC8783388. View Article
Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC. Front Cardiovasc Med. 2021 Aug 30;8:687885. PMID: 34527708. PMC8435633. View Article
Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients
Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E. Front Cardiovasc Med. 2021 Aug 12;8:688396. PMID: 34458332. PMC8387660. View Article
Unbiased Omics Identifies Mechanistic Regulators of Calcific Aortic Valve Disease
Rogers MA, Aikawa E. Eur Heart J. 2021 Aug 7;42(30):2948-50. PMID: 34179985. PMC8095786. View Article
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E. Front Cardiovasc Med. 2021 Jun 22;8:678401. PMID: 34239903. PMC8257952. View Article
ApoA-I Mimetics Improve Aortic Stenosis-Associated Left-Ventricular Diastolic Dysfunction but Fail to Benefit Rabbit Models With Normal Aortic Valves
Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF. Int J Cardiol. 2021 Jun 1;332:159-61. PMID: 33626387. View Article
Old Drugs for an Old Pathology?
Bartoli-Leonard F, Aikawa E. Circ Res. 2021 Apr 30;128(9):1317-9. PMID:33914606. PMC8095786. View Article
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis
Blaser MC, Kraler S, Lüscher TF, Aikawa E. Circ Res. 2021 Apr 30;128(9):1371-97. PMID: 33914608. PMC8095729. View Article
Nitric Oxide Prevents Aortic Valve Calcification by S-nitrosylation of USP9X to Activate NOTCH Signaling
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Sci Adv. 2021 Feb 5;7(6):eabe3706. PMID: 33547080. PMC7864581. View Article
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP. Front Cardiovasc Med. 2021 Feb 3;7:604826. PMID: 33614739. PMC7888299. View Article