Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis
Blaser MC, Kraler S, Lüscher TF, Aikawa E. Circ Res. 2021 Apr 30;128(9):1371-97. PMID: 33914608. PMC8095729. View Article
Nitric Oxide Prevents Aortic Valve Calcification by S-nitrosylation of USP9X to Activate NOTCH Signaling
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Sci Adv. 2021 Feb 5;7(6):eabe3706. PMID: 33547080. PMC7864581. View Article
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP. Front Cardiovasc Med. 2021 Feb 3;7:604826. PMID: 33614739. PMC7888299. View Article
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms
Passos LSA, Nunes MCP, Aikawa E. Front Cardiovasc Med. 2021 Jan 18;7:612716. PMID: 33537348. PMC7848031. View Article
ApoC-III Is a Novel Inducer of Calcification in Human Aortic Valves
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. J Biol Chem. Jan-Jun 2021;296:100193. PMID: 33334888. PMC7948477. View Article
2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders
Aikawa E, Blaser MC. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):117-27. PMID: 33115271. PMC7832175. View Article
Calcific Aortic Valve Disease “Omics” Is Timely, But Are We Looking Too Late?
Atkins SK, Singh SA, Aikawa E. JACC Basic Transl Sci. 2020 Dec 28;5(12):1178-80. PMID: 33427821. PMC7775952. View Article
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes
Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J. JACC Cardiovasc Imaging. 2020 Dec 16;13(12):2513-26. PMID: 32950446. PMC7861508. View Article
Raising Awareness for Rheumatic Mitral Valve Disease
Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E. Glob Cardiol Sci Pract. 2020 Nov 30;2020(2):e202026. PMID: 33426043. PMC7768627. View Article
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves
Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J. JACC Basic Transl Sci. 2020 Nov 25;5(12):1187-206. PMID: 33426376. PMC7775962. View Article