Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis
Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E.…
Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty
Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia…
Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost
Human P, Bezuidenhout D, Aikawa E, Zilla P. Front Cardiovasc Med. 2022 Jan 4;8:760635. PMID: 35059444. PMC8764456. View Article
Controlled Delivery of Gold Nanoparticle-Coupled miRNA Therapeutics via an Injectable Self-Healing Hydrogel
van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer…
Innate and Adaptative Immunity: The Understudied Driving Force of Heart Valve Disease
Bartoli-Leonard F, Zimmer J, Aikawa E. Cardiovasc Res. 2021 Nov 22;117(13):2506-24. PMID:34432007. PMC8783388. View Article
Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC. Front…
Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients
Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA,…
Unbiased Omics Identifies Mechanistic Regulators of Calcific Aortic Valve Disease
Rogers MA, Aikawa E. Eur Heart J. 2021 Aug 7;42(30):2948-50. PMID: 34179985. PMC8095786. View Article
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA,…
ApoA-I Mimetics Improve Aortic Stenosis-Associated Left-Ventricular Diastolic Dysfunction but Fail to Benefit Rabbit Models With Normal Aortic Valves
Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF. Int J Cardiol. 2021 Jun 1;332:159-61. PMID: 33626387.…
Old Drugs for an Old Pathology?
Bartoli-Leonard F, Aikawa E. Circ Res. 2021 Apr 30;128(9):1317-9. PMID:33914606. PMC8095786. View Article
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis
Blaser MC, Kraler S, Lüscher TF, Aikawa E. Circ Res. 2021 Apr 30;128(9):1371-97. PMID: 33914608. PMC8095729. View Article