Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction
Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA,…
Can We Diagnose Acute Rheumatic Fever Early to Maximize the Success of Secondary Prophylaxis in Rheumatic Heart Valve Disease?
Passos LSA, Nizet V, Levine RA, Aikawa E. Cardiovasc Res. 2022 Jul 20;118(9):e62-e65. PMID: 35862716. PMC9890620. View Article
Progression of Aortic Stenosis After an Acute Myocardial Infarction
Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P,…
A Disease-Driver Population Within Interstitial Cells of Human Calcific Aortic Valves Identified via Single-Cell and Proteomic Profiling
Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S,…
The Developmental Origin of Calcific Aortic Stenosis
Aikawa E, Hutcheson JD. N Engl J Med. 2022 Apr 7;386(14):1372-4. PMID: 35388675. View Article
Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition
Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian…
Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling
Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP,…
Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8 + T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease
Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO,…
Calcific Aortic Valve Disease: From Molecular and Cellular Mechanisms to Medical Therapy
Kraler S, Blaser MC, Aikawa E, Camici GG, Lüscher TF. Eur Heart J. 2022 Feb 12;43(7):683-97. PMID: 34849696. PMC8843796. View…
Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis
Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E.…
Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty
Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia…
Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost
Human P, Bezuidenhout D, Aikawa E, Zilla P. Front Cardiovasc Med. 2022 Jan 4;8:760635. PMID: 35059444. PMC8764456. View Article